Manitowoc /ˈmænɪtəwɔːk/ is a city in and the county seat of Manitowoc County, Wisconsin, United States. The city is located on Lake Michigan at the mouth of the Manitowoc River. According to the 2010 census, Manitowoc had a population of 33,736, with over 50,000 residents in the surrounding communities. The city's sister city is Kamogawa, Japan.